Prednisolone Prednisolone, Generic Prednisolone, Prednisolone is in a class of drugs called steroids and reduces swelling and decreases the body's immune response. Prednisolone, Generic Prednisolone, Prednisolone is used to treat many different conditions. Prednisolone, Generic Prednisolone, Prednisolone used to treat endocrine (hormonal) disorders when the body does not produce enough of its own steroids. It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease. Prednisolone, Generic Prednisolone, Prednisolone may also be used for purposes other than those listed in this medication guide. Do not take Prednisolone, Generic Prednisolone, Prednisolone if you have a serious bacterial, viral, or fungal infection. Prednisolone weakens the body's immune response and thus its ability to fight infection.