Drug Name Lisinopril Drug Uses Lisinopril is used to treat elevated blood pressure and heart failure. How to use Lisinopril should be taken at doses specifically directed by the physician. Lisinopril can be taken with or without food. Lisinopril should be taken at the same time each day to maintain consistent blood levels. Lisinopril should not be taken within two hours of taking an antacid since the antacid binds lisinopril and prevents its absorption. Lisinopril is often tapered when discontinuing. Drug Class and Mechanism Lisinopril is an angiotensin converting enzyme (ACE) inhibitor. Angiotensin is a chemical that is made by the body continuously. It narrows blood vessels and thereby maintains (elevates) blood pressure. When the enzyme is blocked by lisinopril, angiotensin cannot be converted into its active form. As a result, blood pressure falls. Interestingly, lisinopril and other ACE inhibitors were developed from the venom of a poisonous Brazilian snake. Missed Dose Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication. Storage Lisinopril should be stored in a dry place at 15-30 degrees C (59-86 degrees F).